Gene expression profiling in multiple sclerosis brain

Gene Expression of CD226 and Its Serum Levels in Patients With Multiple Sclerosis

Background: Recent studies have found some genetic variants as a risk factor for autoimmune diseases such as Multiple Sclerosis (MS). Cluster of Differentiation 226 (CD226) is one of the risk factors for MS.  Objectives: The present study aimed to evaluate the gene expression of CD226, and its protein serum level in peripheral blood samples of MS patients and healthy individuals. Materials & ...

cytokines gene expression in newly diagnosed multiple sclerosis patients.

multiple sclerosis (ms) is characterized by multiple areas of inflammation, demyelination and neurodegeneration. infiltrating th1 cd4+ t cells secrete proinflammatory cytokines. they stimulate the release of some cytokines, expression of adhesion molecules and these cytokines may cause damage to the myelin sheath and axons. in this study, we analyzed plasma levels and gene expressions of five i...

Autoantibody Profiling in Multiple Sclerosis

Insights Arising from Gene Expression Profiling in Amyotrophic Lateral Sclerosis

Gene expression profiling has been used extensively in multiple fields of research to compare disease and control samples, to investigate mechanisms of disease, to identify subtypes within a heterogeneous clinical phenotype and to establish responses to a specific treatment. In addition, it can also be used to determine the function of a gene, to monitor changes over time, or for discovering ce...

Gene expression profiling of metastatic brain cancer.

Gene expression profiling of metastatic brain tumors from primary lung adenocarcinoma, using a 17k-expression array, revealed that 1561 genes were consistently altered. Further functional classification placed the genes into seven categories: cell cycle and DNA damage repair, apoptosis, signal transduction molecules, transcription factors, invasion and metastasis, adhesion, and angiogenesis. Ge...